Peptide Libraray

R2PLx

General Information

DRACP ID DRACP00841

Peptide Name R2PLx

Sequence GIMDTVKNAAKNLAGQLLDKLKCKITAC

Sequence Length 29

UniProt ID Not available

PubChem CID Not available

Origin skin secretions of the pickerel frog (Rana palustris)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=5.90 μM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=15.44 μM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=5.79 μM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=16.14 μM	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=20.19 μM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: Moderate haemolytic activity

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=79.50 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral Mix

Physicochemical Information

Formula C127H224N36O37S3

Absent amino acids EFHPRSWY

Common amino acids K

Mass 344324

Pl 9.55

Basic residues 5

Acidic residues 2

Hydrophobic residues 11

Net charge 3

Boman Index -2156

Hydrophobicity 11.38

Aliphatic Index 104.48

Half Life
/

Extinction Coefficient cystines 125

Absorbance 280nm 4.46

Polar residues 8

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30279210

Title A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells

Doi 10.1042/BSR20180710

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available