This work is licensed under a Creative Commons Attribution 4.0 International License.
S-24-R2Plx
General Information
DRACP ID DRACP00842
Peptide Name S-24-R2Plx
Sequence GIMDTVKNAAKNLAGQLLDKLKCSITAC
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin skin secretions of the pickerel frog (Rana palustris)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=58.18 μM | MTT assay | 24h | 1 |
| MDA-MB-435S | Amelanotic melanoma | Carcinoma | IC50=179.00 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=792.60 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=278.30 μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=316.90 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: Low haemolytic activity
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=1185.00 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C124H219N35O39S3
Absent amino acids EFHPRWY
Common amino acids AKL
Mass 340232
Pl 8.81
Basic residues 4
Acidic residues 2
Hydrophobic residues 11
Net charge 2
Boman Index -1941
Hydrophobicity 22.86
Aliphatic Index 108.21
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 4.63
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30279210
Title A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.