This work is licensed under a Creative Commons Attribution 4.0 International License.
I192W
General Information
DRACP ID DRACP00847
Peptide Name I192W
Sequence GCRLYGFKWHGCG
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=72.9 µM | CCK-8 assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Protein kinase CK2
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys12
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C67H94N20O15S2
Absent amino acids ADEIMNPQSTV
Common amino acids G
Mass 169796
Pl 8.8
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index -872
Hydrophobicity -29.23
Aliphatic Index 30
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 7115
Absorbance 280nm 592.92
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30307134
Title Structure-based Discovery of Novel CK2α-Binding Cyclic Peptides with Anti-cancer Activity
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.