This work is licensed under a Creative Commons Attribution 4.0 International License.
L187V
General Information
DRACP ID DRACP00848
Peptide Name L187V
Sequence GCRVYGFKIHGCG
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=38.9 µM | CCK-8 assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Protein kinase CK2
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys12
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C61H93N19O15S2
Absent amino acids ADELMNPQSTW
Common amino acids G
Mass 161088
Pl 8.8
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index -701
Hydrophobicity 15.38
Aliphatic Index 52.31
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1615
Absorbance 280nm 134.58
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30307134
Title Structure-based Discovery of Novel CK2α-Binding Cyclic Peptides with Anti-cancer Activity
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.