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P-MerP fragment [F5K,A6L,A9R,V13K,V14I]
General Information
DRACP ID DRACP00849
Peptide Name P-MerP fragment [F5K,A6L,A9R,V13K,V14I]
Sequence PMKKLKLALRLAAKIAPVW
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | Not active up to 100 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Not active up to 100 µM | MTT assay | 24h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | Not active up to 100 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: Not active up to 100 µM
Normal (non-cancerous) Cytotoxicity 3T3-L1: Not active up to 100 µM; HUVEC: Not active up to 100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C103H179N27O20S
Absent amino acids CDEFGHNQSTY
Common amino acids AKL
Mass 246905
Pl 12
Basic residues 5
Acidic residues 0
Hydrophobic residues 11
Net charge 5
Boman Index 344
Hydrophobicity 46.32
Aliphatic Index 138.95
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 305.56
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30346140
Title A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies
Doi 10.1021/acsinfecdis.8b00219
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.