HPRP-A1

General Information


DRACP ID  DRACP00858

Peptide Name   HPRP-A1

Sequence  FKKLKKLFSKLWNWK

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50=14.8 µM MTT assay 24h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=22.9 µM MTT assay 24h 1
NCI-H460 Lung large cell carcinoma Carcinoma IC50=13.3 µM MTT assay 24h 1
BGC-823 Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=14.1 µM MTT assay 24h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=15.7 µM MTT assay 24h 1

Hemolytic Activity  Human red blood cells: MHC=32 μM, MHC: the minimum hemolytic concentration is the concentration of peptide that results in 10% hemolysis of human red blood cells (hRBCs).

Normal (non-cancerous) Cytotoxicity  HUVEC: IC50=24.2 μM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00858

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C101H156N24O18

Absent amino acids  ACDEGHIMPQRTVY

Common amino acids  K

Mass  224439

Pl  11.5

Basic residues  6

Acidic residues  0

Hydrophobic residues  7

Net charge  6

Boman Index  -1796

Hydrophobicity  -83.33

Aliphatic Index  78

Half Life 
  Mammalian: 1 hour
  Yeast: 2 min
  E.coli: 2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  785.71

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30592418

Title  Targeted Modification of the Cationic Anticancer Peptide HPRP-A1 with iRGD To Improve Specificity, Penetration, and Tumor-Tissue Accumulation

Doi 10.1021/acs.molpharmaceut.8b00854

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.