ChMAP-28

General Information


DRACP ID  DRACP00863

Peptide Name   ChMAP-28

Sequence  GRFKRFRKKLKRLWHKVGPFVGPILHY

Sequence Length  27

UniProt ID  Not available

PubChem CID  Not available

Origin  Goat Antimicrobial

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia IC50=3.39±0.15 μM MTT assay 48h 1
SK-BR-3 Breast adenocarcinoma Carcinoma IC50=5.63±1.05 μM MTT assay 48h 1
A431 Skin squamous cell carcinoma Carcinoma IC50=6.49±0.09 μM MTT assay 48h 1
B16-F1 Mouse melanoma Carcinoma IC50=4.82±1.01 μM MTT assay 48h 1

Hemolytic Activity  Human erythrocytes: ChMAP-28 has a low hemolytic activity (hemolysis less than 10%) at a concentration range up to 10 μM.

Normal (non-cancerous) Cytotoxicity  HEK293T: IC50=5.09±0.40 μM; HEF: IC50=8.95±2.68 μM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00863

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C163H255N49O29

Absent amino acids  ACDEMNQST

Common amino acids  K

Mass  382905

Pl  12.54

Basic residues  11

Acidic residues  0

Hydrophobic residues  10

Net charge  11

Boman Index  -5504

Hydrophobicity  -65.93

Aliphatic Index  79.26

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  6990

Absorbance 280nm  268.85

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30622471

Title  Anticancer Activity of the Goat Antimicrobial Peptide ChMAP-28

Doi 10.3389/fphar.2018.01501

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.