Peptide Libraray

P-52

General Information

DRACP ID DRACP00864

Peptide Name P-52

Sequence WEQKIEELLKKAEEQQKKNEEELKKLEK

Sequence Length 28

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
TZM-bl	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	50% Cytotoxicity=85.83µM	CellTiter 96 AQueous One Solution assay	48h	1
MT-4	Human acute lymphoblastic leukemia cell line	Leukemia	50% Cytotoxicity=108.32µM	CellTiter 96 AQueous One Solution assay	48h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity PBMC: 50% Cytotoxicity=80.45 µM; HEK293T cells: 50% Cytotoxicity=78.52 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antiviral

Structure Information

PDB ID Not available

Predicted Structure DRACP00864

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C156H261N41O51

Absent amino acids CDFGHMPRSTVY

Common amino acids E

Mass 400881

Pl 5.02

Basic residues 8

Acidic residues 9

Hydrophobic residues 7

Net charge -1

Boman Index -10021

Hydrophobicity -200.36

Aliphatic Index 73.21

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 203.7

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30716118

Title Monotherapy with a low-dose lipopeptide HIV fusion inhibitor maintains long-term viral suppression in rhesus macaques

Doi 10.1371/journal.ppat.1007552

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available