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LP-83
General Information
DRACP ID DRACP00868
Peptide Name LP-83
Sequence WEQKIEELLKKAEEQQKKNEEELKKLEKC
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MT-4 | Human acute lymphoblastic leukemia cell line | Leukemia | 50% Cytotoxicity=19.65µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| C8166 | Human T cell leukemia cells | Leukemia | 50% Cytotoxicity=19.19µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 50% Cytotoxicity=9.97µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| TZM-bl | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity=12.34µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity PBMC: 50% Cytotoxicity=40.27 µM; HEK293T cells: 50% Cytotoxicity=25.31 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Chol-NH2
Other Modification None
Chiral L
Physicochemical Information
Formula C159H266N42O52S
Absent amino acids DFGHMPRSTVY
Common amino acids E
Mass 412979
Pl 5.02
Basic residues 8
Acidic residues 9
Hydrophobic residues 7
Net charge -1
Boman Index -9893
Hydrophobicity -184.83
Aliphatic Index 70.69
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 196.43
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30867304
Title Design and Characterization of Cholesterylated Peptide HIV-1/2 Fusion Inhibitors with Extremely Potent and Long-Lasting Antiviral Activity
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.