Peptide Libraray

BMAP-27(1-18)

General Information

DRACP ID DRACP00870

Peptide Name BMAP-27(1-18)

Sequence GRFKRFRKKFKKLFKKLS

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
MDA-MB-361	Breast adenocarcinoma	Carcinoma	50% Cytotoxicity>100 µM	MTT assay	2 days	1
A549	Lung adenocarcinoma	Carcinoma	50% Cytotoxicity>100 µM	MTT assay	2 days	1

Hemolytic Activity Human erythrocytes: 10% Hemolysis<400 µM; 50% Hemolysis>200 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00870

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C113H188N34O20

Absent amino acids ACDEHIMNPQTVWY

Common amino acids K

Mass 264633

Pl 12.84

Basic residues 10

Acidic residues 0

Hydrophobic residues 6

Net charge 10

Boman Index -6431

Hydrophobicity -128.89

Aliphatic Index 43.33

Half Life
Mammalian: 1.4 hour
Yeast: 3 min
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31226350

Title Structural analysis and mode of action of BMAP-27, a cathelicidin-derived antimicrobial peptide

Doi 10.1016/j.peptides.2019.170106

Year 2019

Literature 2

Pubmed ID 21497177

Title Cell selectivity, mechanism of action and LPS-neutralizing activity of bovine myeloid antimicrobial peptide-18 (BMAP-18) and its analogs

Doi 10.1016/j.peptides.2011.03.024

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available