This work is licensed under a Creative Commons Attribution 4.0 International License.
Cycl-Arenicin-1
General Information
DRACP ID DRACP00872
Peptide Name Cycl-Arenicin-1
Sequence RWCVYAYVRVRGVLVRYRRCW
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL11 positive; Chronic myeloid leukemia | Leukemia | IC50=16.2 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 15% Hemolysis=14 µM; 50% Hemolysis=65.5 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys20; NCB: Arg1<--->Trp21
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C127H195N41O25S2
Absent amino acids DEFHIKMNPQST
Common amino acids R
Mass 311723
Pl 11.15
Basic residues 6
Acidic residues 0
Hydrophobic residues 9
Net charge 6
Boman Index -5485
Hydrophobicity -7.14
Aliphatic Index 92.38
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 15595
Absorbance 280nm 779.75
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31234579
Title Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.