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Mastoparan-L [A5K,L9R,A10I,I13K,L14I]
General Information
DRACP ID DRACP00873
Peptide Name Mastoparan-L [A5K,L9R,A10I,I13K,L14I]
Sequence INLKKLAARIKKKI
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | IC50>100 µM | MTT assay | 2h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>100 µM | MTT assay | 2h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 8% Hemolysis=100 µM
Normal (non-cancerous) Cytotoxicity 3T3-L1: 50% Cell death>100 µM ; HUVEC: 50% Cell death>100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H145N23O16
Absent amino acids CDEFGHMPQSTVWY
Common amino acids K
Mass 186921
Pl 12.05
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -2109
Hydrophobicity -20
Aliphatic Index 153.57
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31411881
Title Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties
Doi 10.1021/acs.jmedchem.9b00915
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.