Peptide Libraray

Mastoparan-L [I1K,N2I,A5R,L9K,A10I]

General Information

DRACP ID DRACP00874

Peptide Name Mastoparan-L [I1K,N2I,A5R,L9K,A10I]

Sequence KILKRLAAKIKKIL

Sequence Length 14

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
PC-3	Prostate carcinoma	Carcinoma	IC50>100 µM	MTT assay	2h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50>100 µM	MTT assay	2h	1
HT-29	Colon adenocarcinoma	Carcinoma	IC50>100 µM	MTT assay	2h	1

Hemolytic Activity Human erythrocytes: 3% Hemolysis=100 µM

Normal (non-cancerous) Cytotoxicity 3T3-L1: 50% Cell death>100 µM ; HUVEC: 50% Cell death>100 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP00874

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C78H150N22O15

Absent amino acids CDEFGHMNPQSTVWY

Common amino acids K

Mass 186827

Pl 12.05

Basic residues 6

Acidic residues 0

Hydrophobic residues 8

Net charge 6

Boman Index -953

Hydrophobicity 32.14

Aliphatic Index 181.43

Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31411881

Title Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties

Doi 10.1021/acs.jmedchem.9b00915

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available