This work is licensed under a Creative Commons Attribution 4.0 International License.
Bac5 (1-17)[P4,9R]
General Information
DRACP ID DRACP00882
Peptide Name Bac5 (1-17)[P4,9R]
Sequence RFRRPIRRRPIRPPFYP
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Leukemia | Not active up to 32 µM | MTT assay | 20h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C106H170N38O19
Absent amino acids ACDEGHKLMNQSTVW
Common amino acids R
Mass 256628
Pl 12.9
Basic residues 7
Acidic residues 0
Hydrophobic residues 4
Net charge 7
Boman Index -8878
Hydrophobicity -154.12
Aliphatic Index 45.88
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 93.13
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31692278
Title Proline-Rich Peptides With Improved Antimicrobial Activity Against E. Coli, K. Pneumoniae, and A. Baumannii.
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.