Bac5 (1-17)[P4W, F15W]

General Information


DRACP ID  DRACP00886

Peptide Name   Bac5 (1-17)[P4W, F15W]

Sequence  RFRWPIRRPPIRPPWYP

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MEC-1 Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia Leukemia 7% Killing=32µM MTT assay 20h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00886

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C112H164N34O19

Absent amino acids  ACDEGHKLMNQSTV

Common amino acids  P

Mass  257628

Pl  12.68

Basic residues  5

Acidic residues  0

Hydrophobic residues  5

Net charge  5

Boman Index  -5726

Hydrophobicity  -137.65

Aliphatic Index  45.88

Half Life 
  Mammalian: 1 hour
  Yeast: 2 min
  E.coli: 2 min

Extinction Coefficient cystines  12490

Absorbance 280nm  780.63

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31692278

Title  Proline-Rich Peptides With Improved Antimicrobial Activity Against E. Coli, K. Pneumoniae, and A. Baumannii.

Doi 10.1002/cmdc.201900465

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.