[Y8S-I11S]cTI

General Information


DRACP ID  DRACP00914

Peptide Name   [Y8S-I11S]cTI

Sequence  KWCFRVCSRGSCYRRCRG

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  host defense peptide from the horseshoe crab Tachypleus tridentatus

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
WM164 Cutaneous melanoma Carcinoma CC50>32 µM Resazurin assay 24h 1
MDA-MB-435S Amelanotic melanoma Carcinoma CC50>32 µM Resazurin assay 24h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia CC50>32 µM Resazurin assay 24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma CC50>32 µM Resazurin assay 24h 1
MM96L Melanoma Carcinoma CC50>32 µM Resazurin assay 24h 1
HT-144 Melanoma Carcinoma CC50>64 µM Resazurin assay 24h 1

Hemolytic Activity  Human RBCs: CC50>32 µM

Normal (non-cancerous) Cytotoxicity  HaCaT: CC50>64 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00914

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys3<--->Cys16; Cys7<--->Cys12

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C92H147N35O22S4

Absent amino acids  ADEHILMNPQT

Common amino acids  R

Mass  252703

Pl  10.46

Basic residues  6

Acidic residues  0

Hydrophobic residues  3

Net charge  6

Boman Index  -7074

Hydrophobicity  -77.78

Aliphatic Index  16.11

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  7240

Absorbance 280nm  425.88

Polar residues  9

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31714739

Title  Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties

Doi 10.1021/acschembio.9b00782

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.