This work is licensed under a Creative Commons Attribution 4.0 International License.
[I11F-G18K]cTI
General Information
DRACP ID DRACP00915
Peptide Name [I11F-G18K]cTI
Sequence KWCFRVCYRGFCYRRCRK
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin host defense peptide from the horseshoe crab Tachypleus tridentatus
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| WM164 | Cutaneous melanoma | Carcinoma | CC50=2.9±0.2 µM | Resazurin assay | 24h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | CC50=1.9±0.1 µM | Resazurin assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | CC50=5.1±0.3 µM | Resazurin assay | 24h | 1 |
| MM96L | Melanoma | Carcinoma | CC50=1.3±0.1 µM | Resazurin assay | 24h | 1 |
| HT-144 | Melanoma | Carcinoma | CC50=3.2±0.1 µM | Resazurin assay | 24h | 1 |
Hemolytic Activity Human RBCs: CC50=8.4±1.2 µM
Normal (non-cancerous) Cytotoxicity HaCaT: CC50=4.1±0.1 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys3<--->Cys16; Cys7<--->Cys12
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C108H164N36O21S4
Absent amino acids ADEHILMNPQST
Common amino acids R
Mass 273435
Pl 10.46
Basic residues 7
Acidic residues 0
Hydrophobic residues 4
Net charge 7
Boman Index -6759
Hydrophobicity -80
Aliphatic Index 16.11
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 8730
Absorbance 280nm 513.53
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31714739
Title Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties
Doi 10.1021/acschembio.9b00782
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.