Peptide Libraray

[R9S-R14S-R17S]cTI

General Information

DRACP ID DRACP00922

Peptide Name [R9S-R14S-R17S]cTI

Sequence KWCFRVCYSGICYSRCSG

Sequence Length 18

UniProt ID Not available

PubChem CID Not available

Origin host defense peptide from the horseshoe crab Tachypleus tridentatus

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	Leukemia	CC50=4.8±0.3 µM	Resazurin assay	24h	1
HT-144	Melanoma	Carcinoma	CC50=11.8±0.9 µM	Resazurin assay	24h	1
WM164	Cutaneous melanoma	Carcinoma	CC50=11.1±0.9 µM	Resazurin assay	24h	1

Hemolytic Activity Human RBCs: CC50=15.3±1.4 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antitumor

Structure Information

PDB ID Not available

Predicted Structure DRACP00922

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys3<--->Cys16; Cys7<--->Cys12

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C92H136N26O24S4

Absent amino acids ADEHLMNPQT

Common amino acids C

Mass 242189

Pl 8.67

Basic residues 3

Acidic residues 0

Hydrophobic residues 4

Net charge 3

Boman Index -2460

Hydrophobicity 10.56

Aliphatic Index 37.78

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 8730

Absorbance 280nm 513.53

Polar residues 11

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 31714739

Title Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties

Doi 10.1021/acschembio.9b00782

Year 2019

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available