This work is licensed under a Creative Commons Attribution 4.0 International License.
Cm-p5 [E4C, H8C]
General Information
DRACP ID DRACP00924
Peptide Name Cm-p5 [E4C, H8C]
Sequence SRSCLIVCQRLF
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | Not active up to 300 µg/ml | PrestoBlue cell viability reagent | overnight | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys8
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C61H105N19O16S2
Absent amino acids ADEGHKMNPTWY
Common amino acids CLRS
Mass 162113
Pl 8.83
Basic residues 2
Acidic residues 0
Hydrophobic residues 5
Net charge 2
Boman Index -1784
Hydrophobicity 83.33
Aliphatic Index 121.67
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 11.36
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31763531
Title Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 With Improved Antifungal Activity.
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.