EeCentrocin 1 Chain A (1-12)[R5A, D8A, N12K]

General Information


DRACP ID  DRACP00929

Peptide Name   EeCentrocin 1 Chain A (1-12)[R5A, D8A, N12K]

Sequence  GWWRATVAKVRK

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A2058 Amelanotic melanoma Carcinoma IC50>200µM MTS assay 1

Hemolytic Activity  Human erythrocytes:0% Hemolysis=25-200 µM

Normal (non-cancerous) Cytotoxicity  MRC-5: IC50>200 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00929

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C68H108N22O14

Absent amino acids  CDEFHILMNPQSY

Common amino acids  AKRVW

Mass  165413

Pl  12.53

Basic residues  4

Acidic residues  0

Hydrophobic residues  6

Net charge  4

Boman Index  -2621

Hydrophobicity  -64.17

Aliphatic Index  65

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  11000

Absorbance 280nm  1000

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 31802582

Title  Structure-activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus

Doi 10.1002/psc.3233

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.