This work is licensed under a Creative Commons Attribution 4.0 International License.
EeCentrocin 1 Chain A (1-16)
General Information
DRACP ID DRACP00935
Peptide Name EeCentrocin 1 Chain A (1-16)
Sequence GWWRRTVDKVRNAGRK
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A2058 | Amelanotic melanoma | Carcinoma | IC50>200µM | MTS assay | 1 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=25-200 µM
Normal (non-cancerous) Cytotoxicity MRC-5: IC50>200 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C87H141N33O21
Absent amino acids CEFHILMPQSY
Common amino acids R
Mass 225301
Pl 12.52
Basic residues 6
Acidic residues 1
Hydrophobic residues 5
Net charge 5
Boman Index -7228
Hydrophobicity -161.88
Aliphatic Index 42.5
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 11000
Absorbance 280nm 733.33
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31802582
Title Structure-activity relationship studies of shortened analogues of the antimicrobial peptide EeCentrocin 1 from the sea urchin Echinus esculentus
Doi 10.1002/psc.3233
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.