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Astacidin PcAst-1b/c
General Information
DRACP ID DRACP00937
Peptide Name Astacidin PcAst-1b/c
Sequence SNVYRPPPYRPVYRPLRRPGYRP
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Procambarus clarkii; Procambarus clarkii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Leukemia | Not active up to 100 µM | MTT assay | 24h | 1 |
| T24 | Bladder carcinoma | Carcinoma | IC50>100 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C132H202N42O30
Absent amino acids ACDEFHIKMQTW
Common amino acids P
Mass 324985
Pl 11.84
Basic residues 6
Acidic residues 0
Hydrophobic residues 3
Net charge 6
Boman Index -8618
Hydrophobicity -156.09
Aliphatic Index 42.17
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5960
Absorbance 280nm 270.91
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31884202
Title Identification and functional characterization of the astacidin family of proline-rich host defence peptides (PcAst) from the red swamp crayfish (Procambarus clarkii, Girard 1852)
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.