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Astacidin PcAst-2
General Information
DRACP ID DRACP00938
Peptide Name Astacidin PcAst-2
Sequence FYPRPYRPPYLPDPRPFPRPLPAFGHEFRRH
Sequence Length 31
UniProt ID Not available
PubChem CID Not available
Origin Procambarus clarkii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Leukemia | Not active up to 100 µM | MTT assay | 24h | 1 |
| T24 | Bladder carcinoma | Carcinoma | IC50>100 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C187H263N53O39
Absent amino acids CIKMNQSTVW
Common amino acids P
Mass 441270
Pl 11.14
Basic residues 8
Acidic residues 2
Hydrophobic residues 7
Net charge 6
Boman Index -9028
Hydrophobicity -129.35
Aliphatic Index 28.39
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 4470
Absorbance 280nm 149
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31884202
Title Identification and functional characterization of the astacidin family of proline-rich host defence peptides (PcAst) from the red swamp crayfish (Procambarus clarkii, Girard 1852)
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.