This work is licensed under a Creative Commons Attribution 4.0 International License.
Turgencin A
General Information
DRACP ID DRACP00942
Peptide Name Turgencin A
Sequence GPKTKAACKXACKLATCGKKPGGWKCKLCELGCDAV
Sequence Length 36
UniProt ID Not available
PubChem CID Not available
Origin Synoicum turgens
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A2058 | Amelanotic melanoma | Carcinoma | IC50=1.4 µM | AqueousOne assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5: IC50=4.8 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys8<--->Cys33; Cys12<--->Cys29; Cys17<--->Cys26
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=MET-OXD
Chiral L
Physicochemical Information
Formula C152H258N44O41S6
Absent amino acids FHIMNQRSY
Common amino acids K
Mass 428487
Pl 9.2
Basic residues 8
Acidic residues 2
Hydrophobic residues 10
Net charge 6
Boman Index -2251
Hydrophobicity -16.94
Aliphatic Index 54.44
Half Life
/
Extinction Coefficient cystines 5875
Absorbance 280nm 167.86
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31940927
Title Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.