This work is licensed under a Creative Commons Attribution 4.0 International License.
Pep-1
General Information
DRACP ID DRACP00945
Peptide Name Pep-1
Sequence KETWWETWWTEWSQPKKKRKV
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin porcine cathelicidin peptide
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50 ≥ 65 µM | MTT assay | 24h | 1 |
Hemolytic Activity RBC: IC50 ≥ 65 µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50 ≥ 65 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Cysteamidation
Other Modification None
Chiral L
Physicochemical Information
Formula C136H195N35O33
Absent amino acids ACDFGHILMNY
Common amino acids KW
Mass 320515
Pl 10.62
Basic residues 6
Acidic residues 3
Hydrophobic residues 6
Net charge 3
Boman Index -6406
Hydrophobicity -203.81
Aliphatic Index 13.81
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 27500
Absorbance 280nm 1375
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32126228
Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Doi 10.1016/j.bbamem.2020.183228
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.