This work is licensed under a Creative Commons Attribution 4.0 International License.
Tritrpticin
General Information
DRACP ID DRACP00975
Peptide Name Tritrpticin
Sequence VRRFPWWWPFLRR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin porcine cathelicidin peptide
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=18.3 µM | MTT assay | 24h | 1 |
Hemolytic Activity RBC: IC50 ≥ 65 µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50=40.6 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification Parent
Chiral L
Physicochemical Information
Formula C96H132N28O14
Absent amino acids ACDEGHIKMNQSTY
Common amino acids R
Mass 211648
Pl 12.98
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index -3777
Hydrophobicity -79.23
Aliphatic Index 52.31
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 16500
Absorbance 280nm 1375
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32126228
Title Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Doi 10.1016/j.bbamem.2020.183228
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.