This work is licensed under a Creative Commons Attribution 4.0 International License.
ROS modulator 1 (58-78)
General Information
DRACP ID DRACP00984
Peptide Name ROS modulator 1 (58-78)
Sequence KTMMQSGGTFGTFMAIGMGIR
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 20% Killing=256 µg/ml | MTT assay | 2h | 1 |
Hemolytic Activity Mouse erythrocytes: 20% Hemolysis=256µg/ml
Normal (non-cancerous) Cytotoxicity HEK293: 20% Hemolysis=256µg/ml; HUVEC: 20% Hemolysis=256µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H156N26O27S4
Absent amino acids CDEHLNPVWY
Common amino acids G
Mass 257960
Pl 11.65
Basic residues 2
Acidic residues 0
Hydrophobic residues 5
Net charge 2
Boman Index -541
Hydrophobicity 34.29
Aliphatic Index 41.9
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32291307
Title Romo1-Derived Antimicrobial Peptide Is a New Antimicrobial Agent against Multidrug-Resistant Bacteria in a Murine Model of Sepsis
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.