This work is licensed under a Creative Commons Attribution 4.0 International License.
Figainin 2
General Information
DRACP ID DRACP00996
Peptide Name Figainin 2
Sequence FLGAILKIGHALAKTVLPMVTNAFKPKQ
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Boana raniceps
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | Carcinoma | IC50=12.8 µM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=15.3 µM | MTT assay | 24h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | Not toxic up to 25 µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 9% Hemolysis=16µM; 23% Hemolysis=32µM; 50% Hemolysis=48.9µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C142H236N36O33S
Absent amino acids CDERSWY
Common amino acids AKL
Mass 348952
Pl 11.28
Basic residues 5
Acidic residues 0
Hydrophobic residues 14
Net charge 5
Boman Index 1085
Hydrophobicity 57.5
Aliphatic Index 118.57
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32443921
Title Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.