This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin-PP
General Information
DRACP ID DRACP00997
Peptide Name Dermaseptin-PP
Sequence ALWKDMLKGIGKLAGKAALGAVKTLV
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Phyllomedusa palliata Skin Secretions
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=1.55 μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=2.92 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=4.15 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=2.47 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: Dermaseptin-PP exhibited only a moderate hemolytic effect (<20% at 16 μM with a calculated HC50 of 38.77 μM)
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C123H214N32O30S
Absent amino acids CEFHNPQRSY
Common amino acids AKL
Mass 309946
Pl 10.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 14
Net charge 4
Boman Index 1605
Hydrophobicity 63.85
Aliphatic Index 131.54
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32582642
Title Novel Frog Skin-Derived Peptide Dermaseptin-PP for Lung Cancer Treatment: In vitro/vivo Evaluation and Anti-tumor Mechanisms Study
Year 2020
Patent
Patent ID CN115637282A
Patent Title Research method of novel antibacterial peptide Dermaeptin-PP
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.