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Kassinatuerin-3
General Information
DRACP ID DRACP00998
Peptide Name Kassinatuerin-3
Sequence FIQHLIPLIPHAIQGIKDIF
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Skin Secretion of the African Frog, Kassina senegalensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-251MG | Astrocytoma | Carcinoma | IC50=13.20 μM | MTT assay | 24h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=3.79 μM | MTT assay | 24h | 1 |
| NCI-H838 | Lung adenocarcinoma | Carcinoma | IC50=10.3 μM | MTT assay | 24h | 1 |
| NCI-H460 | Lung large cell carcinoma | Carcinoma | IC50=1.67 μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=21.54 μM | MTT assay | 24h | 1 |
| NCI-H23 | Lung adenocarcinoma | Carcinoma | IC50=4.52 μM | MTT assay | 24h | 1 |
Hemolytic Activity Human RBCs: Kassinatuerin-3 produced no detectable hemolysis activity up to a concentration of 160 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C113H177N27O25
Absent amino acids CEMNRSTVWY
Common amino acids I
Mass 265293
Pl 7.71
Basic residues 3
Acidic residues 1
Hydrophobic residues 11
Net charge 2
Boman Index 1340
Hydrophobicity 88
Aliphatic Index 161
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32630734
Title A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, Kassina senegalensis
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.