This work is licensed under a Creative Commons Attribution 4.0 International License.
Anoplin [G1Beta-Ala]
General Information
DRACP ID DRACP01000
Peptide Name Anoplin [G1Beta-Ala]
Sequence XLLKRIKTLL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 20% Killing=256 µM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes : <5% Hemolysis=256µM
Normal (non-cancerous) Cytotoxicity HEK293T: 15% Hemolysis=256µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(1)=Beta-Ala
Chiral L
Physicochemical Information
Formula C52H98N14O10
Absent amino acids ACDEFGHMNPQSVWY
Common amino acids L
Mass 135016
Pl 11.82
Basic residues 3
Acidic residues 0
Hydrophobic residues 5
Net charge 3
Boman Index -399
Hydrophobicity 67
Aliphatic Index 195
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32654770
Title Synthesis and anti-pseudomonal activity of new ß-Ala modified analogues of the antimicrobial peptide anoplin
Doi 10.1016/j.ijmm.2020.151433
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.