Desmethoxymajusculamide C

General Information


DRACP ID  DRACP01001

Peptide Name   Desmethoxymajusculamide C

Sequence  XXGXGXXXA

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Lyngbya majuscula

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HCT 116 Colon carcinoma Carcinoma IC50=0.02µM Concentration-cell number assay 120h 1
NCI-H460 Lung large cell carcinoma Carcinoma IC50=0.063µM Concentration-cell number assay 120h 1
MDA-MB-435 Amelanotic melanoma Carcinoma IC50=0.022µM Concentration-cell number assay 120h 1
N2a Mouse neuroblastoma cells Blastoma IC50>1.0µM Concentration-cell number assay 120h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: X(1)<--->Ala9

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate

Chiral  L



Physicochemical Information


Formula  C7HN3O-2

Absent amino acids  CDEFHIKLMNPQRSTVWY

Common amino acids  X

Mass  89798

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  1

Net charge  0

Boman Index  369

Hydrophobicity  11.11

Aliphatic Index  11.11

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19489598

Title  Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms

Doi 10.1021/np9001674

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.