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Linear Desmethoxymajusculamide C
General Information
DRACP ID DRACP01002
Peptide Name Linear Desmethoxymajusculamide C
Sequence XXGXGXXXA
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | IC50=0.016µM | Concentration-cell number assay | 120h | 1 |
| NCI-H460 | Lung large cell carcinoma | Carcinoma | IC50=0.094µM | Concentration-cell number assay | 120h | 1 |
| MDA-MB-435 | Amelanotic melanoma | Carcinoma | IC50=0.23µM | Concentration-cell number assay | 120h | 1 |
| N2a | Mouse neuroblastoma cells | Blastoma | IC50>1.0µM | Concentration-cell number assay | 120h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond NCB: X(1)<--->Ala9
N-terminal Modification Free
C-terminal Modification Free
Other Modification X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Chiral L
Physicochemical Information
Formula C7HN3O-2
Absent amino acids CDEFHIKLMNPQRSTVWY
Common amino acids X
Mass 89798
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index 369
Hydrophobicity 11.11
Aliphatic Index 11.11
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19489598
Title Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.