This work is licensed under a Creative Commons Attribution 4.0 International License.
Esculentin (1-21)
General Information
DRACP ID DRACP01005
Peptide Name Esculentin (1-21)
Sequence GIFSKLAGKKIKNLLISGLKG
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | 50% Cell death=150 µM | MTT assay | 24h | 1 |
Hemolytic Activity Sheep erythrocytes: 10% Hemolysis=64 µM
Normal (non-cancerous) Cytotoxicity HaCat: 20% Killing=64 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C102H181N27O25
Absent amino acids CDEHMPQRTVWY
Common amino acids K
Mass 254266
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 9
Net charge 5
Boman Index 180
Hydrophobicity 33.81
Aliphatic Index 134.76
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32722535
Title Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities
Doi 10.3390/antibiotics9080448
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.