This work is licensed under a Creative Commons Attribution 4.0 International License.
Esculentin (1-18)
General Information
DRACP ID DRACP01007
Peptide Name Esculentin (1-18)
Sequence GIFSKLAGKKLKNLLISG
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | 20% Killing=64 µM | MTT assay | 24h | 1 |
Hemolytic Activity Sheep erythrocytes: 10% Hemolysis=64 µM
Normal (non-cancerous) Cytotoxicity HaCat: 20% Killing=64 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C88H155N23O22
Absent amino acids CDEHMPQRTVWY
Common amino acids KL
Mass 219076
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 8
Net charge 4
Boman Index 149
Hydrophobicity 38.33
Aliphatic Index 135.56
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32722535
Title Frog Skin-Derived Peptides Against Corynebacterium jeikeium: Correlation between Antibacterial and Cytotoxic Activities
Doi 10.3390/antibiotics9080448
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.