This work is licensed under a Creative Commons Attribution 4.0 International License.
Ranatuerin-2SSa
General Information
DRACP ID DRACP01009
Peptide Name Ranatuerin-2SSa
Sequence GLISTIWNTASNVAGTLTDSVKCKFKKC
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Glandirana susurra
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | 80.3% Killing=32µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity COS-7: 88.5% Killing=32µg/ml; CPAE: 99.2% Killing=32µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C131H217N35O40S2
Absent amino acids EHMPQRY
Common amino acids KT
Mass 346828
Pl 9.6
Basic residues 4
Acidic residues 1
Hydrophobic residues 10
Net charge 3
Boman Index -2355
Hydrophobicity 12.14
Aliphatic Index 83.57
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5625
Absorbance 280nm 208.33
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32751229
Title Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens
Doi 10.3390/antibiotics9080457
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.