Peptide Libraray

Brevinin-1H

General Information

DRACP ID DRACP01011

Peptide Name Brevinin-1H

Sequence FALGAVTKVLPKLFCLITRKC

Sequence Length 21

UniProt ID Not available

PubChem CID Not available

Origin skin secretion of Amolops hainanensis

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
PC-3	Prostate carcinoma	Carcinoma	IC50=5.87 μM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=3.47 μM	MTT assay	24h	1
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=3.37 μM	MTT assay	24h	1
HCT 116	Colon carcinoma	Carcinoma	IC50=2.599 μM	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Horse blood cells: HC50=53.12 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antitumor; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP01011

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C109H185N27O24S2

Absent amino acids DEHMNQSWY

Common amino acids L

Mass 267889

Pl 10.51

Basic residues 4

Acidic residues 0

Hydrophobic residues 11

Net charge 4

Boman Index 905

Hydrophobicity 108.1

Aliphatic Index 130

Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 6.25

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 32812694

Title Characterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues

Doi 10.1111/cbdd.13779

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available