This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin-1Ha
General Information
DRACP ID DRACP01012
Peptide Name Brevinin-1Ha
Sequence FALGAVTKVLPKLFCLITRKC
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin skin secretion of Amolops hainanensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | IC50=186.9 μM | MTT assay | 24h | 1 |
| MDA-MB-435S | Amelanotic melanoma | Carcinoma | IC50=214.7 μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=278.9 μM | MTT assay | 24h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=342.8 μM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Horse blood cells: only over 20% at a concentration of 128 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C109H185N27O24S2
Absent amino acids DEHMNQSWY
Common amino acids L
Mass 267889
Pl 10.51
Basic residues 4
Acidic residues 0
Hydrophobic residues 11
Net charge 4
Boman Index 905
Hydrophobicity 108.1
Aliphatic Index 130
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 6.25
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32812694
Title Characterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.