Brevinin-1Ha

General Information


DRACP ID  DRACP01012

Peptide Name   Brevinin-1Ha

Sequence  FALGAVTKVLPKLFCLITRKC

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  skin secretion of Amolops hainanensis 

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
PC-3 Prostate carcinoma Carcinoma IC50=186.9 μM MTT assay 24h 1
MDA-MB-435S Amelanotic melanoma Carcinoma IC50=214.7 μM MTT assay 24h 1
NCI-H157 Lung squamous cell carcinoma Carcinoma IC50=278.9 μM MTT assay 24h 1
HCT 116 Colon carcinoma Carcinoma IC50=342.8 μM MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Horse blood cells: only over 20% at a concentration of 128 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01012

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C109H185N27O24S2

Absent amino acids  DEHMNQSWY

Common amino acids  L

Mass  267889

Pl  10.51

Basic residues  4

Acidic residues  0

Hydrophobic residues  11

Net charge  4

Boman Index  905

Hydrophobicity  108.1

Aliphatic Index  130

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  125

Absorbance 280nm  6.25

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 32812694

Title  Characterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues

Doi 10.1111/cbdd.13779

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.