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Brevinin-1HY
General Information
DRACP ID DRACP01013
Peptide Name Brevinin-1HY
Sequence FALGAVTKVLYKLFCLITRKC
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin skin secretion of Amolops hainanensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | IC50=5.425 μM | MTT assay | 24h | 1 |
| MDA-MB-435S | Amelanotic melanoma | Carcinoma | IC50=2.243 μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=2.811 μM | MTT assay | 24h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | IC50=3.583 μM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Horse blood cells: The haemolysis at the MIC of Brevinin-1HY (28.48%) was more than threefold at the MIC for the parent peptide
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C113H187N27O25S2
Absent amino acids DEHMNPQSW
Common amino acids L
Mass 274495
Pl 10.14
Basic residues 4
Acidic residues 0
Hydrophobic residues 11
Net charge 4
Boman Index 891
Hydrophobicity 109.52
Aliphatic Index 130
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1615
Absorbance 280nm 80.75
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32812694
Title Characterisation of a novel peptide, Brevinin-1H, from the skin secretion of Amolops hainanensis and rational design of several analogues
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.