This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-SHe
General Information
DRACP ID DRACP01019
Peptide Name Temporin-SHe
Sequence FLPALAGIAGLLGKIF
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Pelophylax saharicus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | 45% Killing=12.5µM; 96% Killing=25µM | MTT assay | 72h | 1 |
Hemolytic Activity Human erythrocytes: 22% Hemolysis=12.5µM; 84% Hemolysis=25µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H129N17O17
Absent amino acids CDEHMNQRSTVWY
Common amino acids L
Mass 186877
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 11
Net charge 1
Boman Index 3818
Hydrophobicity 178.13
Aliphatic Index 165
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32933215
Title Functional Characterization of Temporin-SHe, a New Broad-Spectrum Antibacterial and Leishmanicidal Temporin-SH Paralog from the Sahara Frog ( Pelophylax saharicus)
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.