This work is licensed under a Creative Commons Attribution 4.0 International License.
Figainin 1
General Information
DRACP ID DRACP01020
Peptide Name Figainin 1
Sequence FIGTLIPLALGALTKLFK
Sequence Length 18
UniProt ID A0A2L2DDE6
PubChem CID Not available
Origin B. raniceps skin secretion
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | Carcinoma | IC50=10.5 µM (0.020 g/L) | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=13.7 µM (0.026 g/L) | MTT assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=11.1 µM (0.021 g/L) | MTT assay | 24h | 1 |
Hemolytic Activity Human red blood cells: HC50 =10 µM (0.019 g/L) (testing time is 24 h)
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=13 µM (0.025 g/L) (testing time is 24 h)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H158N20O21
Absent amino acids CDEHMNQRSVWY
Common amino acids L
Mass 221985
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 11
Net charge 2
Boman Index 2966
Hydrophobicity 142.22
Aliphatic Index 162.78
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32967114
Title Figainin 1, a Novel Amphibian Skin Peptide with Antimicrobial and Antiproliferative Properties
Doi 10.3390/antibiotics9090625
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.