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C1
General Information
DRACP ID DRACP01021
Peptide Name C1
Sequence CKKKC
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Lipopeptides Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=25.5±2.9 µg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:HC50=43.9±3.5µg/ml
Normal (non-cancerous) Cytotoxicity HaCat: IC50=23.6±6µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys5
N-terminal Modification CH3(CH2)14CO, Palmitic acid
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C24H48N8O6S2
Absent amino acids ADEFGHILMNPQRSTVWY
Common amino acids K
Mass 68035
Pl 9.67
Basic residues 3
Acidic residues 0
Hydrophobic residues 0
Net charge 3
Boman Index -1409
Hydrophobicity -134
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 31.25
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33003569
Title Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.