C6

General Information


DRACP ID  DRACP01022

Peptide Name   C6

Sequence  CKKKRC

Sequence Length  6

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Lipopeptides Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=30.4±2.5µg/ml MTT assay 24h 1

Hemolytic Activity  Human erythrocytes:HC50=71±6.4µg/ml

Normal (non-cancerous) Cytotoxicity  HaCat: IC50=45.7±13.5µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP01022

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys1<--->Cys6

N-terminal Modification  CH3(CH2)14CO, Palmitic acid

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C30H60N12O7S2

Absent amino acids  ADEFGHILMNPQSTVWY

Common amino acids  K

Mass  85437

Pl  10.51

Basic residues  4

Acidic residues  0

Hydrophobic residues  0

Net charge  4

Boman Index  -2901

Hydrophobicity  -186.67

Aliphatic Index  0

Half Life 
  Mammalian: 1.2 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  125

Absorbance 280nm  25

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33003569

Title  Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity

Doi 10.3390/ijms21197208

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.