This work is licensed under a Creative Commons Attribution 4.0 International License.
vCPP 2319
General Information
DRACP ID DRACP01028
Peptide Name vCPP 2319
Sequence WRRRYRRWRRRRRWRRRPRR
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=5.02±1.04 µM | CellTiter-Blue assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>200µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C137H228N68O22
Absent amino acids ACDEFGHIKLMNQSTV
Common amino acids R
Mass 351877
Pl 13.31
Basic residues 15
Acidic residues 0
Hydrophobic residues 3
Net charge 15
Boman Index -21695
Hydrophobicity -365.5
Aliphatic Index 0
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 17990
Absorbance 280nm 946.84
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33015016
Title To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.