This work is licensed under a Creative Commons Attribution 4.0 International License.
Orc1
General Information
DRACP ID DRACP01030
Peptide Name Orc1
Sequence RRIPFWPPNLPGPRRPPWFLPDFRIPRIPRKR
Sequence Length 32
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Leukemia | 40% Killing=32µM | MTT assay | 20h | 1 |
Hemolytic Activity Human erythrocytes:0% Hemolysis=32µM
Normal (non-cancerous) Cytotoxicity HaCat: 15% Killing=32µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C193H296N60O36
Absent amino acids ACEHMQSTVY
Common amino acids P
Mass 458592
Pl 12.98
Basic residues 9
Acidic residues 1
Hydrophobic residues 10
Net charge 8
Boman Index -10113
Hydrophobicity -111.25
Aliphatic Index 60.94
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 354.84
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33036159
Title Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.