This work is licensed under a Creative Commons Attribution 4.0 International License.
Cathelicidin-like peptide Lip1
General Information
DRACP ID DRACP01033
Peptide Name Cathelicidin-like peptide Lip1
Sequence RRIRIRPPRLPRPRPRPWFPPRFPIPRIPGKR
Sequence Length 32
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MEC-1 | Chronic lymphocytic leukemia; B-cell chronic lymphocytic leukemia | Leukemia | 90% killing=32μM | MTT assay | 20h | 1 |
Hemolytic Activity Human erythrocytes:0% Hemolysis=32µM
Normal (non-cancerous) Cytotoxicity HaCat: 10% Killing=32µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C188H309N67O33
Absent amino acids ACDEHMNQSTVY
Common amino acids PR
Mass 458900
Pl 13.5
Basic residues 12
Acidic residues 0
Hydrophobic residues 8
Net charge 12
Boman Index -13584
Hydrophobicity -140.31
Aliphatic Index 60.94
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 177.42
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33036159
Title Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.