This work is licensed under a Creative Commons Attribution 4.0 International License.
AMP2
General Information
DRACP ID DRACP01036
Peptide Name AMP2
Sequence KRWWKWWRR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| OVCAR-3 | High grade ovarian serous adenocarcinoma | Carcinoma | IC50=53.5 µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H102N24O10
Absent amino acids ACDEFGHILMNPQSTVY
Common amino acids W
Mass 163064
Pl 12.81
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -4654
Hydrophobicity -276.67
Aliphatic Index 0
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 2750
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33184577
Title Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Doi 10.1007/s12195-020-00626-z
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.