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DAP2
General Information
DRACP ID DRACP01038
Peptide Name DAP2
Sequence RWGKWFKKNSHLS
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 48h | 1 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 48h | 1 |
| NCI/ADR-RES | High grade ovarian serous adenocarcinoma | Carcinoma | IC50>100 µM | MTT assay | 48h | 1 |
| T24 | Bladder carcinoma | Carcinoma | IC50>100 µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HUVEC: IC50>100 μM; NL20: IC50>100 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C79H116N24O17
Absent amino acids ACDEIMPQTVY
Common amino acids K
Mass 188815
Pl 11.92
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -3617
Hydrophobicity -154.62
Aliphatic Index 30
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 916.67
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33184577
Title Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Doi 10.1007/s12195-020-00626-z
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.