This work is licensed under a Creative Commons Attribution 4.0 International License.
AMP1
General Information
DRACP ID DRACP01039
Peptide Name AMP1
Sequence WKWLKKWIK
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| OVCAR-3 | High grade ovarian serous adenocarcinoma | Carcinoma | IC50=51.1 µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H102N16O10
Absent amino acids ACDEFGHMNPQRSTVY
Common amino acids K
Mass 145855
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -537
Hydrophobicity -111.11
Aliphatic Index 86.67
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 2062.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33184577
Title Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Doi 10.1007/s12195-020-00626-z
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.