This work is licensed under a Creative Commons Attribution 4.0 International License.
HS3
General Information
DRACP ID DRACP01041
Peptide Name HS3
Sequence CGAISLAKLQINES
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CT26 | Mouse colon adenocarcinoma | Carcinoma | IC50=80.7±6.9 µM | MTT assay | 24, 48, 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target programmed cell death protein 1
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C61H107N17O21S
Absent amino acids DFHMPRTVWY
Common amino acids AILS
Mass 167876
Pl 6.23
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index -582
Hydrophobicity 45
Aliphatic Index 125.71
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33360579
Title Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.